Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors
نویسندگان
چکیده
منابع مشابه
Preparation and biodistribution study of 99mTc-EC-Annexin-SPIO as a tracer of radiation induced apoptosis in mice model
Introduction: Apoptosis is a major consequence of ionizing radiation in proliferative tissues and quantification of the apoptotic cells could be helpful for noninvasive assessment and estimation of the radiation absorbed dose. Annexin V conjugated with super paramagnetic iron oxide nanoparticles (ANX-SPIO) is a biological probe for detection of apoptotic cells using magnetic resonance imaging. ...
متن کاملIn vivo and in vitro measurement of apoptosis in breast cancer cells using 99mTc-EC-annexin V.
OBJECTIVE The purpose of this study was to develop an imaging technique to measure and monitor tumor cells undergoing programmed death caused by radiation and chemotherapy using 99mTc-EC-annexin V. Annexin V has been used to measure programmed cell death both in vitro and in vivo. Assessment of apoptosis would be useful to evaluate the efficacy and mechanisms of therapy and disease progression ...
متن کاملRadionuclide Imaging of Apoptosis in Malignancies: Promise and Pitfalls of 99mTc-Hynic-rh-Annexin V Imaging
Radionuclide detection of apoptosis with of (99m)Tc-Hynic-rh-Annexin V scintigraphy is an effective tool for in vivo visualisation and monitoring of apoptosis in various malignant tumour. Early therapy-induced increase of the tumour tracer uptake correlates with favourable outcome, whereas stable or decreased uptake correlates with stable disease or tumour progression. Therefore sequential (99m...
متن کاملApoptosis imaging: beyond annexin V.
Induction of apoptosis is the primary mechanism through which most chemotherapies cause tumor cell death. Early assessment of tumor response is required to manage patients in terms of quality of life versus intensive chemotherapy. Although imaging with radiolabeled annexin V has been intensively investigated, it is still not sufficiently mature for clinical application. This article will summar...
متن کاملpreparation and biodistribution study of 99mtc-ec-annexin-spio as a tracer of radiation induced apoptosis in mice model
introduction: apoptosis is a major consequence of ionizing radiation in proliferative tissues and quantification of the apoptotic cells could be helpful for noninvasive assessment and estimation of the radiation absorbed dose. annexin v conjugated with super paramagnetic iron oxide nanoparticles (anx-spio) is a biological probe for detection of apoptotic cells using magnetic resonance imaging. ...
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ژورنال
عنوان ژورنال: Applied Radiation and Isotopes
سال: 2008
ISSN: 0969-8043
DOI: 10.1016/j.apradiso.2008.01.012